The benefits of corticosteroids in lupus treatment can be measured in terms of increased life expectancy. In 1955, the survival rate at five years for lupus patients was only 50%. By 1995, the survival rate at 20 years had already reached 80%. In fact, many women stay healthy to keep their works for decades after diagnosis with lupus disease.
Even though corticosteroids have a benefit in lupus treatment, the risks of corticosteroids are serious enough to warrant very careful dosage adjustments and monitoring, as well as the addition of steroid-sparing drugs. The doctor describes both long term and short term side effects. The short term effects, which can generally be reversed by decreasing the dose, are:
- Mood changes. Some feel energetic and euphoric, while others feel depressed or irritable. Different people react differently.
- Facial hair. Some patients notice coarser or more plentiful facial hair.
- High blood sugar. Diabetics may require a change in their therapy, and patients at risk for diabetes need careful monitoring.
- Acne. This may start or get worse with corticosteroids.
- Increased risk of infections. Since inflammation is our first line of defense against infections of all types, all anti-inflammatory medications increase the risk. Corticosteroids are powerful enough to be of great concern.
- Water retention or Swelling. These medications influence the body’s transport of salts. Patients may notice swelling at some part of the body especially of the ankles.
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