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This research identifies an antibody that induces a protective effect in vivo in a lab rat model of lupus nephritis. The lupus nephritis-model mice that were treated with this antibody experienced a dramatic increase in survival, demonstrated a reduced immune complex formation deposition in the kidneys, and displayed low levels of proteinuria as compared with untreated mice. The antibody is an autospecific anti-dsDNA IgM.
In addition, this invention may be used as a component of a predictive diagnostic kit. As lupus-related kidney disease may be asymptomatic, significant kidney damage may occur before lupus is diagnosed. The researchers are currently investigating whether the ratio of protective antibodies to nonprotective or pathogenic antibodies in lupus nephritis models is predictive of disease. Currently ready diagnostic methods (proteinuria, creatine clearance, or kidney biopsy) are not predictive and test only for existing kidney impairment or damage.
April 7th, 2010 at 12:32 pm
[...] is the original: IgM anti-dsDNA antibodies for the treatment and prevention of … By admin | category: the treatment | tags: lab-rat, protective-effect, research, [...]
April 8th, 2010 at 4:09 pm
It’s nice to read about advances in research that can help people. From what I understand with this should improve the diagnosis. And this is great progress, right?
April 9th, 2010 at 12:46 pm
Prevention is better than cure ….
April 15th, 2010 at 3:35 pm
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August 9th, 2010 at 6:05 am
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